F95.1 F95.2
Conditions
Interventions
Group 1: Arm 1: Patients with tic disorder will be interviewed once and asked to perform computerized tasks with Deep Brain Stimulation turned on.
The following assessments will be performed:
1) Cari
Sponsors
Klinik für Stereotaxie und Funktionelle Neurochirurgie, Klinikum der Universität zu Köln
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - Fluent in the German language - Age 18 to 65 years - Chronic motor tic disorder (F95.1) or chronic motor and vocal tic disorder (F95.2) as main diagnosis according to the International Classification of Diseases 10 (ICD 10) - Deep brain stimulation (Percept PC Neurostimulator)
Exclusion criteria
Exclusion criteria: - Active suicidal ideation - Current psychotic symptomatology - Active or recent substance abuse (except intake of cannabis-based substances, if consumed for treatment of tics) - Serious systemic medical disease - Severe neurological disorder of the central nervous system such as stroke, epilepsy, neoplasia - Mental retardation - Withdrawal of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Urge correlated connectivity between cortical areas (SMA, PFC, ACC) and the DBS target in the theta (4-8 Hz) and beta (15-30 Hz) frequency bands. | — |
Secondary
| Measure | Time frame |
|---|---|
| 2) Movement planning and movement execution-correlated connectivity between cortical areas (SMA, PFC) and DBS target in the delta (1-4 Hz) and theta (4-8 Hz) frequency band. 3) Connectivity between cortical areas (SMA, PFC, ACC) and DBS target in the delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), and beta (15-30 Hz) frequency bands at rest. 4) Modulation of connectivity profiles in 1., 2., & 3. by THS. | — |
Countries
Germany
Contacts
Public ContactThomas Schüller
Klinik für Psychiatrie und Psychotherapie, Klinikum der Universität zu Köln
Outcome results
None listed