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Comparative evaluation of aloe vera gel and platelet rich fibrin in the treatment of intrabony defects in chronic periodontitis patients- a clinical study

Comparative evaluation of aloe vera gel and platelet rich fibrin in the treatment of intrabony defects in chronic periodontitis patients- a clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00029067
Enrollment
60
Registered
2022-06-22
Start date
2020-12-17
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K05.6 K05.6

Interventions

Group 1: Access flap surgery: Open flap debridement Group 2: Access flap surgery: Open flap debridement with placement of aloe vera gel Group 3: Access flap surgery: Open flap debridement with placeme

Sponsors

The Oxford Dental College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 55 Years

Inclusion criteria

Inclusion criteria: Age range of 30-55 years, diagnosed with generalized periodontitis as per World Workshop Classification criteria, who had not received periodontal therapy, within preceding six months, periodontal pocket depth of = 5mm after phase I periodontal therapy, presence of 2- or 3-walled intra-bony defects (IBDs) with radiographic depth =3 mm and platelet count >2,00,000/mm3

Exclusion criteria

Exclusion criteria: Patients who were smokers and alcoholics, pregnant, lactating females and post-menopausal women, if they had vitamin D deficiency, systemically compromised patients and those on medications (corticosteroids/ bisphosphonate, statin therapy, blood thinners) that may interfere with wound healing, grade II and grade III tooth mobility, patients who had undergone periodontal treatment within a period of past 1 year and patients with systemic conditions like blood dyscrasias, allergic reactions, renal, cardiovascular, liver, pulmonary diseases, uncontrolled diabetes and hypertension.

Design outcomes

Primary

MeasureTime frame
The primary outcome was based on the percentage of bone fill following the surgical procedure and assessed at 3, 6 and 9 months

Secondary

MeasureTime frame
The secondary outcome was based on improvement in periodontal clinical parameters assessed at 3, 6 and 9 months

Countries

India

Contacts

Public ContactAnkita Ghosh

The Oxford Dental College

ankitaghosh.doc@gmail.com919900525948

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026