Prospective investigation of the morphology-based risk score for colon carcinoma stratification

Prospective investigation of the morphology-based risk score for colon carcinoma stratification - MBR

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00029012

Enrollment

300

Registered

2022-08-03

Start date

2022-04-26

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C18

Interventions

Group 1: MBR-Score low Group 2: MBR-Score intermediate Group 3: MBR-Score high

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) Initial diagnosis of untreated colon carcinoma (NOS), UICC stage I – II, R0 (2) Treatment in the University Hospital Augsburg or in one of the partner hospitals (3) Availability of sufficient tumor material (paraffin block and/or fresh tissue) or sections (4) Written consent from the patient to participate in the study

Exclusion criteria

Exclusion criteria: (1) Neoadjuvant therapy of colon carcinoma (2) Patients unable to consent (3) Insufficient understanding of the German language (4) Patients with chronic inflammatory bowel disease (5) Patients with hereditary colorectal cancer syndromes (such as Lynch syndrome, familial adenomatous polyposis)

Design outcomes

Primary

Measure	Time frame
PFS at 36 months, stratified by MBR score, UICC and NCCN	—

Secondary

Measure	Time frame
(1) CSS at 60 months stratified by MBR score, UICC and NCCN. (2) Practicability of the MBR score. (3) interobserver reliability.	—

Countries

Germany

Contacts

Public ContactBruno Märkl

Universitätsklinikum Augsburg

pathologie@uk-augsburg.de0831-400 2150

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026