Determination of folate bioavailability in fermented dairy products

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00028996

Enrollment

Registered

2022-05-16

Start date

2022-05-09

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MTHFR- genes, content of homocysteine, content of hemoglobin, vitamin B12 level

Interventions

Group 1: Folate-free control (drink from commercial whey) Group 2: Fermented whey drink Group 3: 5-methyltetrahydrofolate substance (1x 400 µg)

Eligibility

Sex/Gender

All

Age

18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Healthy female and male subjects, aged 18 to 30 years; Caucasian, BMI <30 kg/m2; nonsmokers; written informed consent

Exclusion criteria

Exclusion criteria: Current participation in intervention study; active smokers; alcohol abuse; vitamin B12 deficiency/increased homocysteine level/hemoglobin deficiency; chronic diseases; pregnant and lactating women; blood donation in the last 3 months, known allergies or intolerances to any of the tested foods (dairy products)

Design outcomes

Primary

Measure	Time frame
Course of plasma folate levels on the three study days after the respective intervention	—

Secondary

Measure	Time frame
Folate uptake capacity with inferences on folate bioavailability, differences between subjects and genders, influence of methylenetetrahydrofolate reductase (MTHFR) genotype.	—

Countries

Germany

Contacts

Public ContactLisa Obermaier

Lehrstuhl für Analytische Lebensmittelchemie

lisa.obermaier@tum.de+49 8161 71 6395

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 9, 2026