K80-K87
Conditions
Interventions
Group 1: Comparison of stool and tissue microbiomes of pancreatitis and IPMN patients (serving as tumor precursors with and increased tumor risk) with the stool and tissue microbiome of patients with
Sponsors
Universitätsklinikum Heidelberg. Dept. Allgemeine, Viszerale und Transplantations Chirurgie
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Pancreatic diseases (pancreatitis, IPMN, PDAC).
Exclusion criteria
Exclusion criteria: not pancreatic disease.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Determination of risk bacteria strains in stool and/or tissue of pancreatitis and IPMN patients with increased pancreatic cancer risk. | — |
Primary
| Measure | Time frame |
|---|---|
| Determination of the fecal, and intra-tumoral microbiome in patients with tumor precursor lesions (pancreatitis and IPMN patients) and in pancreatic carcinoma patients. Stool samples from healthy volunteers and healthy pancreatic tissue from the transplantation programs will be used as microbiome controls. Comparisons will be made between the different bacterial strains (the microbiome) and the pancreatic cancer prognosis. Stool samples are collected just before surgery and tissue are collected during the surgery. Healthy volunteers serve as controls for the stool samples. Unused pancreatic tissue from the transplant program serves as control tissue. The respective microbiome will be determined by 16s sequencingon stool and tissue and compared to disease (pancreatitis, IPMN versus pancreatic cancer). | — |
Countries
Germany
Contacts
Public ContactFranco Fortunato
Universitätsklinikum Heidelberg, Chirurgische Klinik, Sektion Chirurgische Forschung,
Outcome results
None listed