G70.0 G62.9 G72.9
Conditions
Interventions
Group 1: Testing using TIS-study protocol correlated with muscle ultrasound on patients with myasthenia gravis, 1 time point of evaluation
Group 2: Testing using TIS-study protocol correlated with mus
Sponsors
Universitätsmedizin Göttingen
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Healthy subjects: 1. Male and female healthy participants between the ages of 18-40. 2 Free willing participation and written, informed consent of all subjects obtained prior to the start of the study Patients: 1. Male and female participants over the age of 18 2. Free willing participation and written, informed consent of all subjects obtained prior to the start of the study. 3. Reliable diagnosis of any neuromuscular disease as indicated below
Exclusion criteria
Exclusion criteria: Healthy subjects: 1. History or evidence of chronic or residual neurological or muscle related disease in the study applicant or family history of the applicant 2. Pacemaker, Metal implants in the body. 3. Age; 40 years old. 4. Any serious medical conditions (disease of the internal organs) or psychiatric illness, including schizophrenia, mania or depression. 5. Pregnancy or breast-feeding. 6. Alcohol, medication or drug addiction. 7. Any legal reason why the candidate cannot participate. 8. Participation in another scientific or clinical study within the last 8 weeks. 9. Active or suspected malignancy (cancer) 10. Sensory loss in the area to be stimulated 11. Severe paresis or complete plegia of the area to be stimulated 12. Acute dermatological conditions 13. Diagnosed neuromuscular, cardiac, or respiratory disorders Patients with NMD: 1. Unclear neuromuscular symptoms without existing reliable diagnosis 2. Neuromuscular disease not indicated in the entities included in this study 3. Pacemaker, Metal implants in the body. 4. Age < 18 old. 5. Any serious medical conditions (disease of the internal organs) or psychiatric illness, including schizophrenia, mania or depression. 6. Pregnancy or breast-feeding. 7. Alcohol, medication or drug addiction. 8. Any legal reason why the candidate cannot participate. 9. Active or suspected malignancy (cancer) 10. Sensory loss in the area to be stimulated 11. Severe paresis or complete plegia of the area to be stimulated 12. Acute dermatological conditions 13. Diagnosed cardiac, or respiratory disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| What: Compliance and apittude of the use of TIS in patients with different neuromuscular disorders When: End of data collection for each patient How: Results of TIS-measurement (used frequency, amplitude, pain threshold), results of ultrasound correlation (muscle contraction, semiquantitative scale), correlation with disease specific parameters (diagnosis, disease duration..) | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences in response of nerve-muscle unit to usage of TIS on peripheral skeletal muscle in patients with different neuromuscular disorders as well as compared to measurements of healthy controls. | — |
Countries
Germany
Contacts
Public ContactAndrea Antal
Universitätsmedizin Göttingen, Klinik für Neurologie
Outcome results
None listed