Post-/Long-COVID U09.9
Conditions
Interventions
Group 1: In the case of proven SARS-CoV-2 infection and if symptoms persist for at least four weeks after the acute infection, three examinations will be performed over the course of one year.
At stud
Sponsors
Universitätsklinikum RWTH Aachen
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Adult study participants - Patients with a proven SARS-CoV-2 infection - Presence of a written declaration of consent of the study participant in case of capacity to give consent
Exclusion criteria
Exclusion criteria: Study participants with incorporated metallic implants will not be allowed. Pregnancy or lactation, traumatic brain injury, neurological or psychiatric disease (except for the neurological disease under study for patients), relevant and severe other medical conditions, e.g. metabolic, endocrinological or cardiac disorders, mental retardation, magnetic metallic implants (including intrauterine coil). Other exclusion criteria: - Body mass index (BMI, weight [kg]/height2 [cm2]) of >30. Medical conditions: - Epilepsy Conditions: - Pregnancy - Uncertain knowledge of any pregnancy present Contraceptives: - Any type of intrauterine device - Copper IUD Metal-containing implants or devices in/on the body (all non-metal-containing implants / devices / patches will be subject to close scrutiny based on the MRI Safety Listing www.mrisafety.com): - Pacemaker / Implanted pacemaker wires. - Implanted defibrillator - Drug pump / infusion device - Pacing device / electrodes - Non-MRI capable implants e.g. surgical screws, plates, nails, etc. - Vascular/lumen filters, wire rings, wire spirals, stents, vascular clips - Artificial heart valve - Transdermal patches - Epithesis (or partial epithesis) - Shunts, catheters, wire sutures Metal in/on the body: - Splinter / gunshot injuries - Metal splinters in the eye, even if everything has supposedly been removed - piercing Dental metals: - Any type of implant in the jawbone area / dental implant older than 20 years. - No contraindication: amalgam fillings, inlays, crowns, single teeth covered with crown gold as a denture support point for a type of denture called a telescopic denture, fixed screw dentures Other: - Cochlear implant - tympanostomy tube - tattoos/permanent make-up (only after careful examination and special permission)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systematic, longitudinal assessment of neurological, neuropsychological, and fluid (blood and stool samples) findings and MRI-based CNS changes after SARS-CoV-2 infection. | — |
Secondary
| Measure | Time frame |
|---|---|
| Identification of clinical, fluid and imaging biomarkers, risk factors and predictors of post-COVID-19 syndrome. | — |
Countries
Germany
Contacts
Public ContactJulia Bungenberg
Universitätsklinikum RWTH Aachen
Outcome results
None listed