Evaluation of the effect of total intravenous and inhalation anesthesia on tumor growth

Evaluation of the effect of total intravenous and inhalation anesthesia on tumor growth - Effect of anesthesia on tumor growth

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00028966

Enrollment

Registered

2022-05-20

Start date

2022-05-02

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C25 C18 C22

Interventions

Group 1: Inhalation anesthesia Patients receive Thiopental for the initiation and sevoflurane as maintanance anesthesia. Both arms contain standard anesthesia protocols - none of them is experimental

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: No age limit Patients with colorectal, pancreatic, hepatocellular and cholangiocellular carcinoma

Exclusion criteria

Exclusion criteria: - muscular disease with disposition for malingant hyperthermia - history of propofol-Infusion syndrome (PRIS) - pregnant women - breast feeding women - no written infomed consent - inability to provide written informed consent - emergency cases - ASA >4

Design outcomes

Primary

Measure	Time frame
The primary study endpoint is the size of subcutaneous metastases in a nude mouse model from single cell suspensions from resected tumor specimen.	—

Secondary

Measure	Time frame
Beta-Cathenin activation in peripheral immune cells (PBMC) and tumor cells.	—

Countries

Germany

Contacts

Public ContactStefan Heinrich

Allgemein-, Viszeral- u. Transplantationschirurgie Universitätsmedizin Mainz

stefan.heinrich@unimedizin-mainz.de+49 6131 17 7291

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026