Cranial MRI and fMRI with chemosensory stimulation examining patients with persisting chemosensory dysfunction post COVID-19

Cranial MRI and fMRI with chemosensory stimulation examining patients with persisting chemosensory dysfunction post COVID-19 - fMR_Chemo_post_Covid

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00028908

Enrollment

Registered

2023-01-10

Start date

2023-07-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

U09.9

Interventions

Group 1: Inclusion criteria first cohort with chemosensory dysfunction: TDI score < 31 (treshold, discrimination, identification test, sniffin`sticks, Burghart Messtechnik GmbH, Germany), and TS = 3

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - age = 18 years - declaration of consent in written form - previous participation in the COVIDOM-study at the UKSH Campus Kiel

Exclusion criteria

Exclusion criteria: - claustrophobia with the need to take tranquilizers for MRI - allergy to fragrances - non-removable implants, e.g. pacemakers, device for deep brain stimulation, insulin-pump/implanted blood glucose meter - every form of chemosensory dysfunction, which goes back to any root cause other than COVID-19 infection (e.g. traumatic brain injury, pregnancy, chronic sinusitis with and without polyposis, allergic and non-allergic rhinitis, neurodegenerative disorders (e.g. Morbus Alzheimer, Morbus Parkinson) - pregnancy - alcoholism

Design outcomes

Primary

Measure	Time frame
It will be examined, which morphological and functional differences there are between individuals who have been infected with COVID-19 and suffer persisting chemosensory dysfunction, and those who have been infected but not affected by chemosensory dysfunction. The goal hereby is to gain information regarding the pathophysiological root cause in persisting chemosensory dysfunction in COVID-19. The results of the study will be the results of chemosensory tests, as well as results of the MRI- and fMRI-examination (like volume and appearance of relevant brain regions, as well as brain activity resulting chemosensory stimulation).	—

Measure

Time frame

It will be examined, which morphological and functional differences there are between individuals who have been infected with COVID-19 and suffer persisting chemosensory dysfunction, and those who have been infected but not affected by chemosensory dysfunction. The goal hereby is to gain information regarding the pathophysiological root cause in persisting chemosensory dysfunction in COVID-19. The results of the study will be the results of chemosensory tests, as well as results of the MRI- and fMRI-examination (like volume and appearance of relevant brain regions, as well as brain activity resulting chemosensory stimulation).

—

Secondary

Measure	Time frame
The gained data will also be examined in context of other factors like age, sex, previous illness, course of COVID-19 infection.	—

Countries

Germany

Contacts

Public ContactMartin Laudien

Klinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie; Phoniatrie und Pädaudiologie

martin.laudien@uksh.de+49 431 500-21715

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026