Improving glucose homeostasis
Conditions
Interventions
Group 1: Long chain Inulin, 15 g per day, for 7 days
Group 2: Corn-bran arabinoxylans, 15g per day, for 7 days
Group 3: Placebo: Maltodextrin, 7,9 g per day, for 7 days
Sponsors
Gottfried Wilhelm-Leibniz-Universität Hannover Institut für Lebensmittelwissenschaft und Humanernährung
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: -Age: 30-65 years -Willingness to take part on the whole study procedure -Omnivorous diet -normoglycemic, healthy
Exclusion criteria
Exclusion criteria: -Severe chronic diseases -diagnosed blood coagulation disorders as well as taking anticoagulant drugs e.g. Marcumar (except ASS) -Known allergy or intolerance to components of the test products -Abuse of alcohol and drugs -Participation in another clinical study within the last 30 days -Pregnancy or lactation -Planned operation in the next 3 months -Use of prebiotics, probiotics or antibiotics 3 months prior
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting and postprandial SCFA plasma concentrations (acetate, butyrate and propionate). -Collected via blood sampling at time points t1;0min., t1;30min., t1;90min., t1;120min., t1;180min., t2;0min., t2;30min., t2;90min., t2;120min., t2;180min. t3;0min., t3;30min., t3;90min., t3;120min., t3;180min. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Fasting and postprandial glucose and insulin concentrations - Satiety and appetite ratings using paper-based visual analogue scales - H2 breath excretion using gas analyses device (Gastrolyzer®) - Fecal gut microbiota composition (16S rRNA gene sequencing) - Gastrointestinal Symptoms Scoring (GSRS questionnaire) - Quality of life questionnaire (SF-36) - Anthropometry ( height, length, waist circumference) - Blood pressure - Sociodemographic measures ( age, sex, education, profession) - AST, ALT, ?GT (liver and kidney safety markers) | — |
Countries
Germany
Contacts
Public ContactMattea Müller
Gottfried Wilhelm-Leibniz-Universität Hannover Institut für Lebensmittelwissenschaft und Humanernährung
Outcome results
None listed