G20
Conditions
Interventions
Group 1: 5 week digital cognitive training with HeadApp / NEUROvitalis
Group 2: passive wait-list control group
Sponsors
Universität zu Köln
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with IPD according to the UK Brain Bank criteria (Gibb & Lees, 1988). 2. Advanced stage disease, defined as IPD patients who meet = 1 of the 5-2-1 criteria: 5 intakes of levodopa tablets per day and/or 2 hours of "OFF" time per day and/or 1 hour of troublesome dyskinesia per day (Antonini et al., 2018; Santos-García et al., 2020) or receive pump therapy 3. Patients who are cognitively unimpaired or have only suspected MCI (MoCA > 21 points; Dalrymple-Alford et al., 2010) 4. Patients who have stable medication within the last 4 weeks before training and between baseline and posttest 5. Age: 18 years and older; all genders 6. German as native language or sufficiently good knowledge of German 7. Access to a computer, laptop or tablet with internet access
Exclusion criteria
Exclusion criteria: 1. Dementia according to level 1 diagnostics (MoCA < 21 points; Dalrymple-Alford et al., 2010) 2. Major depression (BDI-II = 29 points; Beck et al., 1996). 3. Epilepsy and other diseases with seizure-like manifestations and/or disorders of consciousness (ICD-10 G40) 4. Other neurological or psychiatric illness; acute life-threatening illness (self-report in medical history and physician's letters).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Global cognition (MoCA; baseline, posttest + follow-up; measurement procedure administered by a blinded test administrator) | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline only: cognitive reserve (LEQ; questionnaire) All of the following endpoints will be conducted at baseline, posttest, and 3-month follow-up by a blinded test administrator: 1. neuropsychological measurement procedures to measure specific cognitive functions and fluid intelligence: CERAD plus test battery, BTA, WMS-R forward and backward number span, Benton Judgement of Line Orientation Form H (short version), LPS subtest 4 and subtest 9, ACL auditory language comprehension subtest. 2. measurement of motor skills: UPDRS-III, Hoehn & Yahr, Timed Up and Go 3. questionnaires (self-report): Quality of Life (PDQ-39), Subjective Cognitive Impairment (SCI), Depressive Symptomatology (BDI-II), Fatigue (FSMC), Apathy (AES), Self-Efficacy (SWE), Progression Anxiety (PA-F-KF), Activities of Daily Living (B-ADL), Non-Motor Symptomatology (NMSQ), Fear of Falling (FES), Freezing of Gait (FOG-Q), Sleep Quality (PDSS), Physical activity (PASE) | — |
Countries
Germany
Contacts
Public ContactPaulina Olgemöller
Medizinische Psychologie | Neuropsychologie und Gender Studies, Medizinische Fakultät und Uniklinik Köln, Universität zu Köln
Outcome results
None listed