The role of interpretation biases and physiological stress reactivity in the familial transmission of depression

The role of interpretation biases and physiological stress reactivity in the familial transmission of depression - CoCo

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00028842

Enrollment

100

Registered

2022-08-19

Start date

2022-12-16

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F32 F33

Interventions

Group 1: The four-week, primarily app-based interpretation bias training condition consists of a cognitive reappraisal component, a CBM-I component and interpretation bias specific if / then plans. I

Eligibility

Sex/Gender

All

Age

10 Years to 14 Years

Inclusion criteria

Inclusion criteria: Parents, with or without experience of depression, secure in German language

Exclusion criteria

Exclusion criteria: psychiatric disorder in the child; bipolar, psychotic or substance abuse in the parent

Design outcomes

Primary

Measure	Time frame
We have two primary outcomes reflecting our two hypotheses. The first primary outcome (hypothesis 1) is interpretation bias which will be measured via the Scrambled Sentences Task (SST; Everaert, Duyck & Koster, 2014) pre and post the interpretation bias training, with approximately four weeks between assessment timepoints. The second primary outcome (hypothesis 2) is stress reactivity which will be measured via cortisol obtained from saliva swabs pre and post the interpretation bias training, again, with approximately four weeks between assessment timepoints. During each assessment session, cortisol will be sampled at six timepoints (pre-Trier Social Stress Test for Children [TSST-C; Buske Kirschbaum et al.,1997] immediately post, 10 minutes post, 20 minutes post, 30 minutes post and 45 minutes post-TSST-C). Furthermore, simultaneously to the saliva swabs, stress reactivity will be assessed via participants’ change in current mood, using the 9-point affective valence scale of the Self-Assessment Mannequin (SAM; Lang, 1980). The measurement timepoints for the SAM will be the same as those of the saliva swabs.	—

Measure

Time frame

We have two primary outcomes reflecting our two hypotheses. The first primary outcome (hypothesis 1) is interpretation bias which will be measured via the Scrambled Sentences Task (SST; Everaert, Duyck & Koster, 2014) pre and post the interpretation bias training, with approximately four weeks between assessment timepoints. The second primary outcome (hypothesis 2) is stress reactivity which will be measured via cortisol obtained from saliva swabs pre and post the interpretation bias training, again, with approximately four weeks between assessment timepoints. During each assessment session, cortisol will be sampled at six timepoints (pre-Trier Social Stress Test for Children [TSST-C; Buske Kirschbaum et al.,1997] immediately post, 10 minutes post, 20 minutes post, 30 minutes post and 45 minutes post-TSST-C). Furthermore, simultaneously to the saliva swabs, stress reactivity will be assessed via participants’ change in current mood, using the 9-point affective valence scale of the Self-Assessment Mannequin (SAM; Lang, 1980). The measurement timepoints for the SAM will be the same as those of the saliva swabs.

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Secondary

Measure	Time frame
During the four-week app-based interpretation bias training, ecological momentary assessment (EMA) will be used to sample participants’ 1) stress on a given day, 2) how well they could cope with this stress and 3) if they were able to use the strategies learnt via the interpretation bias training from the current intervention to cope with this stress. Participants will be sent a notification on their phone two times a week over a four-week period reminding them about their training task and asking them to answer these three questions.	—

Measure

Time frame

During the four-week app-based interpretation bias training, ecological momentary assessment (EMA) will be used to sample participants’ 1) stress on a given day, 2) how well they could cope with this stress and 3) if they were able to use the strategies learnt via the interpretation bias training from the current intervention to cope with this stress. Participants will be sent a notification on their phone two times a week over a four-week period reminding them about their training task and asking them to answer these three questions.

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Countries

Germany

Contacts

Public ContactBelinda Platt

Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie

Belinda.Platt@med.uni-muenchen.de089 4400 56932

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jul 31, 2026