Mechanobiological characterisation of the herniated intervertebral disc before and after light activated riboflavin collagen cross-linking

Mechanobiological characterisation of the herniated intervertebral disc before and after light activated riboflavin collagen cross-linking - LARC

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00028752

Enrollment

500

Registered

2022-06-03

Start date

2023-01-31

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M51

Interventions

Group 1: Spatial spectroscopic characterization of IVDs/IVD-Herniations and correlation with clinical, radiologic and IVD-proteomic patient data. Extracellular matrix (ECM) characterization of IVDs/IV

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with IVD herniations/advanced degeneration requiring surgical resection.

Exclusion criteria

Exclusion criteria: Patients unable to consent.

Design outcomes

Primary

Measure	Time frame
• Spatial spectroscopic characterization of IVDs and correlation with clinical, radiologic and IVD-proteomic patient data • Extracellular matrix (ECM) characterization of IVDs prior and after LARC treatment with optical coherence tomography (OCT) • ECM characterization of IVDs prior and after LARC treatment with atomic force microscopy (ATM) • Biomechanical evaluation of IVDs prior and after LARC treatment.	—

Measure

Time frame

• Spatial spectroscopic characterization of IVDs and correlation with clinical, radiologic and IVD-proteomic patient data • Extracellular matrix (ECM) characterization of IVDs prior and after LARC treatment with optical coherence tomography (OCT) • ECM characterization of IVDs prior and after LARC treatment with atomic force microscopy (ATM) • Biomechanical evaluation of IVDs prior and after LARC treatment.

—

Secondary

Measure	Time frame
• Spatiotemporal proteomic characterization of IVDs. • Evaluation of inflammation markers and correlation with clinical and radiologic patient data.	—

Countries

Germany

Contacts

Public ContactJürgen Beck

Klinikum der Universität Freiburg, Klinik für Neurochirurgie

j.beck@uniklinik-freiburg.de0761 270 50060

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026