Influence and persistence of positive framing on placebo and nocebo effects of an active placebo nasal spray

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00028711

Enrollment

Registered

2022-04-22

Start date

2022-04-25

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy participants

Interventions

Group 1: nasal spray (active placebo consisting of sesame oil + 0.0007% capsaicin) + positive framing Group 2: nasal spray (active placebo consisting of sesame oil + 0.0007% capsaicin) + no framing G

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Healthy participants

Exclusion criteria

Exclusion criteria: studying or working in medicine, pharmacy or psychology

Design outcomes

Primary

Measure	Time frame
Assessment of the intensity, number, perceived threat and drug attribution of adverse events (post-application, post-experiment 6h after experiment) --> Generic Assessment of Side Effects Scale (GASE)	—

Secondary

Measure	Time frame
Sadness after 2 different sadness induction protocols --> Negative Affect Schedule - Expanded Form (PANAS-X; Watson & Clark, 1999)	—

Countries

Germany

Contacts

Public ContactMarcel Wilhelm

Philipps-Universität Marburg

marcel.wilhelm@uni-marburg.de064212823617

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026