T86.10 T86.11 T86.12 T86.19
Conditions
Interventions
Group 1: Kidney transplant patients are included at the time of deterioration of graft function with indication for renal biopsy. Immunological tests will be performed in parallel. Arm 1 includes pati
Sponsors
Charité Campus Virchow-Klinikum
Eligibility
Sex/Gender
All
Age
18 Years to 110 Years
Inclusion criteria
Inclusion criteria: - Condition after kidney transplant or non-kidney transplant control - Deterioration of transplant function and indication for renal transplant biopsy - Signed informed consent form - Age >18 years - Existing health insurance
Exclusion criteria
Exclusion criteria: - Age under 18 years - Lack of capacity to give consent - Lack of written informed consent - viral infections such as hepatitis B, hepatitis C or/and HIV
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnosis of acute T-cell mediated rejection according to Banff classification in renal biopsy during the observation period (6 months) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Other pathologic findings on renal biopsy - Evolution of glomerular filtration rate, creatinine level, protein in urine, and BK viral load in blood and urine during the study period - Graft failure/loss - Requirement for dialysis - Therapeutic interventions, need for immunosuppressive medications during the observation period (6 months) | — |
Countries
Germany
Contacts
Public ContactConstantin Thieme
Charité - Universitätsmedizin BerlinBIH Center for Regenerative Therapies (BCRT)Berlin Center for Advanced Therapies (BeCAT)
Outcome results
None listed