Extending the Data-Driven Characterization of Neural Markers During Deep Brain Stimulation for Patients with Parkinson’s Disease

Extending the Data-Driven Characterization of Neural Markers During Deep Brain Stimulation for Patients with Parkinson’s Disease - PD-Interaktiv I

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00028703

Enrollment

Registered

2022-04-25

Start date

2023-01-12

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G20

Interventions

Group 1: Step 1: Implantation of DBS and ECoG electodes. 2nd step: Experimental measurements over 5 days. 3rd step: implantation of cables and generator for conventional continuous stimulation. Follow

Eligibility

Sex/Gender

All

Age

35 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Patients diagnosed with PD according to UK PDS Brain Bank Criteria. 2. Written informed consent. 3. Patients who are eligible for STN DBS surgery according to the guidelines of the DGN

Exclusion criteria

Exclusion criteria: 1. Contraindication for stereotactic neurosurgery or other surgery. 2. Dementia (Mattis Dementia Rating Score = 130). 3. Acute psychosis assessed by a psychiatric physician. 4. Inability to give written informed consent. 5. Medications that are likely to cause interactions in the opinion of the investigator. 6. Fertile women not using adequate contraceptive methods. 7. Current or planned pregnancy, nursing period. 8. Contraindication for undergoing MRI. 9. Contraindication for undergoing Diathermy (either shortwave, microwave, and/or ultrasound diathermy). 10. Patient incapable to follow and perform the task instructions

Design outcomes

Primary

Measure	Time frame
O1: Understanding the influence of previously applied stimulation patterns onto the current motor performance. O2: Detection and characterization of novel, potentially multivariate, neural markers. O3: Investigation of neural markers derived from electrocorticogram signals. O4: Characterization of alternative stimulation strategies.	—

Secondary

Measure	Time frame
O2: Detection and characterization of novel, potentially multivariate, neural markers for decoding of motor peformance. End-point: average performance difference (in r-values) between the subject-specific decoding models that incorporate EEG features and the STN LFPs model	—

Countries

Germany

Contacts

Public ContactVolker Coenen

Klinik für NeurochirurgieAbteilung für Stereotaktische und Funktionelle Neurochirurgie

volker.coenen@uniklinik-freiburg.de0761 270-50630

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026