Mechanisms of Immunmodulation in Septic Shock via Early Extracorporeal Hemadsorption

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00028628

Enrollment

140

Registered

2022-03-25

Start date

2022-03-30

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic Shock

Interventions

Group 1: Randomization: early elimination of cytokines via Cytosorb Group 2: Randomization: no Cytosorb Group 3: Observational group, no randomization: patients with septic shock but without possibili

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Septic shock with hyperinflammation, Age > 18y, written consent

Exclusion criteria

Exclusion criteria: Age > 85y, acute coronary syndrome, severe drug-induced immunosuppression, fatal co-morbidity

Design outcomes

Primary

Measure	Time frame
Reduction of cumulative vasopressor-dose after 72h	—

Secondary

Measure	Time frame
Moleculare analyses of humoral and celullar immune responses, organ dysfunction, length of mechanical ventilation, length of ICU stay	—

Countries

Germany

Contacts

Public ContactChristopher Lotz

Universitätsklinikum Würzburg

lotz_c@ukw.de0931-20130001

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026