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Pathogenicity of Aspergillus fumigatus in invasive pulmonary aspergillosis under different host conditions – establishment of a human cell culture model for Early identification of patients with impaired antifungal immune response

Pathogenicity of Aspergillus fumigatus in invasive pulmonary aspergillosis under different host conditions – establishment of a human cell culture model for Early identification of patients with impaired antifungal immune response

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00028609
Enrollment
50
Registered
2022-03-28
Start date
2021-10-08
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

B44.0

Interventions

Group 1: he main aim is to investigate the influence of the function of human NG under different host conditions in the defense against A. fumigatus in the lungs in vitro: neutrophils from healthy vol

Sponsors

Universitätsklinikum Essen
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: signed informed consent, age > 18 years, no pre-existing conditions

Exclusion criteria

Exclusion criteria: age < 18 years, not fullfillling the inclusion criteria

Design outcomes

Primary

MeasureTime frame
occurrence of Aspergillus fumigatus measured as OD I in the platelet reader—

Secondary

MeasureTime frame
Differences in activity profiles of neutrophile granulocytes (NGs) of the healthy volunteers.—

Countries

Germany

Contacts

Public Contactsimon dubler

Universitätsklinikum Essen. Klinik für Anästhesie und Intensivmedizin

simon.dubler@uk-essen.de+4920172384053

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026