healthy proband:in
Conditions
Interventions
Group 1: There will be two identical study days
(4 hours each) will take place. The two study days differ depending on the orally administered sugar:
Mixture 1: 2 g [U13C]-glucose + after 45 min 75
Sponsors
DLR, Institut für Luft- und Raumfahrtmedizin
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: - Age 18 -45 years - Male or female - Healthy - Written informed consent
Exclusion criteria
Exclusion criteria: - Not proficient in the German language - Fructose intolerance - Acute or chronic illness - History of liver or kidney disease - History of diabetes mellitus - Blood glucose =100 mg/dl in fasting state or blood glucose =200 mg/dl in non-fasting State - BMI 4 cups of coffee/black tea per day) - Smoker - Pregnancy (early pregnancy test before each study day). - Menopause - No physical activity - Extreme or high intensity sports - Intense exercise within one week prior to the test day - Illness with prolonged bed rest within 6 weeks prior to test day - Hemophobia (no fear of 10 blood tests)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In order to develop a better understanding of fructose metabolism in humans and to serve as supporting knowledge for future fructose studies in hypoxic conditions, blood concentrations of fructose, glucose, insulin, free fatty acids, and triglycerides will be measured. Indirect calorimetry serves to assess changes in substrate oxidation rate following fructose loading. | — |
Countries
Germany
Contacts
Public ContactJan Schmitz
DLR – Institut für Luft- und Raumfahrtmedizin
Outcome results
None listed