Pathophysiology of neurogenic orthostatic hypotension in patients with multisystem atrophy - A functional MRI study.

Pathophysiology of neurogenic orthostatic hypotension in patients with multisystem atrophy - A functional MRI study. - MSA-fMRI

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00028593

Enrollment

Registered

2022-03-22

Start date

2020-08-24

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multisystematrophy

Interventions

Group 1: The entire examination takes place on one day at DLR and lasts about 3-4 hours. First, functional tests of the autonomic nervous system are performed (e.g. deep breathing, pressing). Subsequ

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Fulfilling clinical criteria for possible or probable MSA - Fulfilling criteria for orthostatic hypotension

Exclusion criteria

Exclusion criteria: - Metal implants or other osteosynthesis material, stents, clips, etc. - Pacemaker, infusion pump, neuro-stimulator, inner ear implant. - Claustrophobia - Permanent makeup - Recent metal work (e.g., flex work where metal particles have remained in the body) - (Piercings and acupuncture needles need to be removed). - Pregnancy

Design outcomes

Primary

Measure	Time frame
NOH in MSA has devastating consequences for the level of functioning and is difficult to treat. A precise knowledge of the origins of orthostatic dysfunction would pave the way for new therapeutic strategies, including medical and surgical (e.g. deep brain stimulation) options. Moreover, the study will provide novel physiological insight in human baroreflex regulation at the brainstem level and may help to better distinguish between different neurodegenerative diseases as well as for early diagnosis.	—

Measure

Time frame

NOH in MSA has devastating consequences for the level of functioning and is difficult to treat. A precise knowledge of the origins of orthostatic dysfunction would pave the way for new therapeutic strategies, including medical and surgical (e.g. deep brain stimulation) options. Moreover, the study will provide novel physiological insight in human baroreflex regulation at the brainstem level and may help to better distinguish between different neurodegenerative diseases as well as for early diagnosis.

—

Countries

Germany

Contacts

Public ContactKathrin Giehl

Abteilung für NuklearmedizinUniklinik Köln

kathrin.giehl@uk-koeln.de0221 478-82841

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026