Skip to content

The impact of weight and weight loss on central insulin function in older individuals

The impact of weight and weight loss on central insulin function in older individuals - age_weight

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00028576
Enrollment
50
Registered
2022-03-21
Start date
2015-11-30
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight Otherwise healthy

Interventions

Group 1: diet group (3-months caloric restriction, individual diet scheme provided by the nutrition department of the UKE) Group 2: active waiting group (3-months, psychoeducation, stressmanagement, m

Sponsors

Universitätsklinikum Hamburg-Eppendorf, Institut für Systemische Neurowissenschaften
Lead Sponsor

Eligibility

Sex/Gender
All
Age
56 Years to No maximum

Inclusion criteria

Inclusion criteria: wish to lose weight, BMI > 25 kg/m²

Exclusion criteria

Exclusion criteria: current or previous psychiatric or neurological disorders, chronic and acute physical illness including diabetes, current psychopharmacological medication as well as MR-specific exclusion criteria. No participant followed any specific diet at the start of the experiment. To exclude systematic confounds during food evaluation, severe food allergies and adherence to a vegan diet constituted further exclusion criteria.

Design outcomes

Primary

MeasureTime frame
BMI assessment after 3-months intervention, measured via bodyweight and height

Secondary

MeasureTime frame
Central insulin activation after 3-months intervention, measured via fMRI activation following intranasal insulin application

Countries

Germany

Contacts

Public ContactStefanie Brassen

Universitätsklinikum Hamburg-Eppendorf, Institut für Systemische Neurowissenschaften

sbrassen@uke.de040741054865

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026