Analysis of two different fatigue entities in Post-Covid-19 and fibromyalgia patients
Conditions
Interventions
Group 1: Biological methods analyze the participation on the pathophysiology of oxidative cell stress and biological effects of a mindfulness-based therapy in patients with Post-Covid-19 fatigue (inte
Sponsors
Klinik für Psychosomatische Medizin und Psychotherapie
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) Post-Covid patients Inclusion Criteria: • Patients between the ages of 18 and 80 who were infected with Covid-19 at least 3 months ago and who suffer from typical post-Covid symptoms of fatigue-like symptoms and limited physical performance. • Other post-Covid symptoms such as shortness of breath, headaches, smell and taste disorders, subjectively experienced cognitive deficits, depressive or anxious symptoms or sensory disorders. 2) FMS patients Inclusion Criteria: • Patients between the ages of 18 and 80 years with a confirmed diagnosis by a neurologist or rheumatologist via FMS according to the 2010 ACR criteria. 3) Control group to post-Covid group People who have recovered from an infection with SARS-CoV-2 and continue to have so-called post-Covid symptoms after this infection and receive medical support in the clinic, but no specialized mindfulness-based therapy for 4 weeks. The patient group acts as a control with regard to the success of the therapy in order to rule out that the symptoms improved purely for reasons of time. These control patients also take part in two survey days, the time interval is organized similarly to the patient group with a break of 4 weeks.
Exclusion criteria
Exclusion criteria: 1) Post-Covid patients Exclusion criteria: • Excluded are people who are acutely addicted and show acute suicidal tendencies, who have psychotic disorders who require long-term medication that has a proven influence on the oxidative cell metabolism (e.g. levodopa for the treatment of Parkinson's or medications containing N-acetylcysteine ??and other antioxidants such as vitamin C), are demented, do not have sufficient knowledge of German, are not sufficiently fit to carry out the study program and cannot easily reach the Nuremberg Clinic from their place of residence. 2) FMS patients Exclusion criteria: • Other rheumatological or orthopedic differential diagnoses that could explain the pain. • Abnormalities in routine blood tests • Psychiatric disorders • Polyneuropathy • Cancer (in the last 5 years) • Drugs (nicotine) or alcohol abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Pathophysiological involvement of oxidative and nitrosative cell stress in fatigue symptoms in two different fatigue groups - post-infectious fatigue in post-Covid patients and fatigue in FMS patients - at rest, under experimental stress and during regeneration. | — |
Secondary
| Measure | Time frame |
|---|---|
| 2) Effects of a mindfulness-based multimodal therapy concept on fatigue - symptoms of both groups using bioanalytical and psychometric methods. | — |
Countries
Germany
Contacts
Public ContactAlexandra Braun
Klinik für Psychosomatische Medizin und Psychotherapie
Outcome results
None listed