Agrammatism R47.0
Conditions
Interventions
Group 1: The study encompasses four separate fMRI task-based experiments i.e., four separate study groups. The experiments employ within-subjects design, so every participant in each study group will
Sponsors
Director of Division of Cognitive Clinical Sciences at RWTH University Clinic
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: General: Age from 18 years; German as first language; Right-handedness (using the Edinburgh Handedness Inventory). For patients: Broca's aphasia with agrammatic speech production and the ability to use at least two-word utterances (aphasia and its severity are classified using the Aachen Aphasia Test (AAT); Etiology: stroke.
Exclusion criteria
Exclusion criteria: For healthy subjects only: confounding neurological disease (e.g., history of traumatic brain injury), dementia, or cognitive impairment the degree of which interferes with participation in the study. For patients: other neurological diseases and disorders (e.g. neurocognitive disorder due to dementia). General: Other basic physical illnesses that interfere with the examination due to their type and severity or have an impact on the parameters to be examined; Mental or behavioral disorder that may interfere with the investigation or acute suicidality; Drug, alcohol, or painkiller abuse; Pregnancy; Presence of electromagnetically influenced or metal-containing medical devices in or in constant connection with the body (e.g. pacemakers, drug pumps, cochlear implants); Presence of metal parts in the body (e.g. screws after a bone fracture, metal splinters, metal prostheses, non-MR compatible vessel clips); a known seizure disorder (epilepsy); Heart and/or brain surgery; Hypersensitivity to TMS for Experiment 3 (will be ruled out during recruitment)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of the present study is to investigate neuronal correlates of morpho-syntactic processing during normal and agrammatical speech production with functional magnetic resonance imaging (fMRI). | — |
Secondary
| Measure | Time frame |
|---|---|
| The further aim of the study is to investigate the functional reorganization patterns of the language production network in the brain after damage to the language regions during expressive agrammatism and after short-term disruption of Broca's area (using transcranial magnetic stimulation (TMS)) with functional magnetic resonance imaging (fMRI). | — |
Countries
Germany
Contacts
Public ContactFerdinand C. Binkofski
Director of Division of Cognitive Clinical Sciences at RWTH University Clinic
Outcome results
None listed