Esophageal Cancer
Conditions
Interventions
Group 1: Selective oral decontamination of the esophagus 7 days prior to operation, intraoperatively and 5 days postoperatively.
Sponsors
Universitätsklinikum Halle (Saale)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: • Patients =18 years • Histologically confirmed esophageal squamous cell or adenocarcinoma • Planned elective esophagectomy with intrathoracic anastomosis
Exclusion criteria
Exclusion criteria: • Patients <18 years • Complete dysphagia with inability to orally ingest the study drug • Known allergies or intolerances against the above-mentioned drugs • Inability to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infectious complications after esophageal resection (composite of pneumonia, anastomotic leakage, empyema, mediastinitis, surgical site infection in hospital / 30 day, whatever is longer) | — |
Secondary
| Measure | Time frame |
|---|---|
| • Overall postoperative morbidity (in hospital / 30 day, whatever is longer) • Postoperative mortality (in hospital / 30 day, whatever is longer) • Adverse events attributed to the intervention • Time to full oral diet • Length of hospital stay • Overall and esophagus-specific quality of life (FACT-E questionnaire) • Changes in the esophageal microbiome | — |
Countries
Germany
Contacts
Public ContactJohannes Klose
Universitätsklinikum Halle (Saale)
Outcome results
None listed