Coagulation and wound healing of open vs. minimally invasive esophageal and pancreatic surgery - focus on factor XIII

Coagulation and wound healing of open vs. minimally invasive esophageal and pancreatic surgery - focus on factor XIII - OPEN-MIC-XIII Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00028547

Enrollment

200

Registered

2022-04-14

Start date

2022-09-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acquired deficiency of clotting factor XIII

Interventions

Group 1: Measurement of factor XIII and other coagulation parameters of patients with open esophageal surgery Group 2: Measurement of factor XIII and other coagulation parameters of patients with mini

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Age = 18 years - Existing capacity to give consent - Patients undergoing esophageal/pancreatic surgery - Present written consent

Exclusion criteria

Exclusion criteria: - Pregnancy - Inclusion in another interventional study - Refusal to participate in the study

Design outcomes

Primary

Measure	Time frame
- Do the different surgical techniques/wound surfaces in open vs. minimally invasive surgery in the esophagus and pancreas affect factor XIII activity? - Do perioperative complications (bleeding complications, anastomotic insufficiencies and wound healing disorders) correlate with coagulation factor XIII activity?	—

Secondary

Measure	Time frame
-Prevalence of FXIII deficiency? -Perioperative course of FXIII levels? -Correlation of factor XIII with transfusion requirements? -Correlation of FXIII activity and duration of ventilation, length of intensive care stay and 28d mortality?	—

Countries

Germany

Contacts

Public ContactMaik von der Forst

Klinik für AnästhesiologieUniversitätsklinikum Heidelberg

Maik.Forst@med.uni-heidelberg.de06221-56-32939

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026