satiety, glucose metabolism, effects on microbiome
Conditions
Interventions
Group 1: Daily consumption of three beverages containing Allulose for the duration of 4 weeks. The amount of allulose (g) corresponds to the amount of sucrose that would deliver 5.1% of the individual
Sponsors
Max Rubner-Institut
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: • BMI 18,5 – 30 kg/m² • No intended weight change • Good general Health • Written informed consent to participate in the study • No diseases that affect nutrient absorption, digestion, metabolism or excretion, especially malabsorption or indigestion of fructose • Clinical parameters for liver and kidney function, carbohydrate and fat metabolism and inflammation markers indicating absence of disease • No indication of restrictive eating behavior (Dutch Eating Behavior Questionnaire (DEBQ)) • Non- Smokers • No acute/regular intake of medication that affects fat or carbohydrate metabolism, or gastrointestinal tract • No intake of antibiotics in the prior 6 months • No pregnancy or lactation peroid • Absence of allergy / intolerance against any foods used in the study.
Exclusion criteria
Exclusion criteria: • Necessity to take certain medications during the study participation • Appearance of undesirable events • Appearance of acute diseases during the study participation • Revocation of consent to participate in the study • Non-compliance with the study protocol (including hygiene procedures)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in postprandial concentrations of active GLP-1 in the plasma | — |
Secondary
| Measure | Time frame |
|---|---|
| • Postprandial plasma concentrations of gut hormones (GIP, PYY, CKK) • Postprandial changes in respiratory quotient • Blood glucose outcomes (Blood glucose, Insulin, c-Peptide, HbA1c, Matsuda Insulin sensitivity index, miRNA) • Metabolite profiles (including sugar profile) in stool, urine, saliva and serum • microbiome composition in stool, urine and saliva • Assessment of the capability of fecal bacteria to degrade Allulose, if applicable isolation, identification and characterization of these gut bacteria • Quantification of bacteria in feces that have the ability to degrade allulose. • Glut5 transporter expression • Excretion rate of allulose | — |
Countries
Germany
Contacts
Public ContactStudienzentrum für Humanstudien
Max Rubner-Institut
Outcome results
None listed