Neurofilament light chain (NfL) levels in long term clinical course of patients with relapsing remitting multiple sclerosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00028507

Enrollment

100

Registered

2022-04-01

Start date

2022-05-02

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G35

Interventions

Group 1: Single-arm trial: Patients with multiple sclerosis will do one study visit. During this visit, blood will be drawn which will be analyzed for NfL.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Diagnosis of relapsing remitting multiple sclerosis (RRMS) or clinical isolated syndrome with RRMS during the disease course Sufficient biobanked material

Exclusion criteria

Exclusion criteria: No consent No capacity to consent acute cerebral lesion (head trauma, stroke, e.g.) <12 months prior to lumbar puncture or planned study visit, chronic disease with elevated neuronal cell death (dementia, motoneuron disease)

Design outcomes

Primary

Measure	Time frame
Korrelation of NfL Levels in biobanked material with neurological status at study visit	—

Secondary

Measure	Time frame
Korrelation of NfL Levels over time, correlation of NfL levels with cerebral imaging	—

Countries

Germany

Contacts

Public ContactTimo Volk

Universitätsklinikum Freiburg - Klinik für Neuologie und Neurophysiologie

timo.volk@uniklinik-freiburg.de076127050010

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026