M17.1
Conditions
Interventions
Group 1: Oral delivery of 40mg Undenatured Collagen Type II (UC II) per day.
Group 2: Placebo Control
Sponsors
Orthopädie im MediaparkMediaPark Klinik Köln
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: Sufficiently severe gonarthrosis grade II and III according to the nativradiological criteria according to Kellgren/Lawrence or magnetic resonance imaging criteria according to Outerbridge. Diagnosis confirmed by standard X-ray (AP, lateral, patella tangential, Rosenberg, whole leg) or MRI Age: 50-70 years VAS 3-7 Gender: both
Exclusion criteria
Exclusion criteria: Exclusion criteria (knee-related) - Arthrofibrosis - Extension deficit ( 100°) - Insufficiency of the anterior and/or posterior cruciate ligament - Intra-articular injections with corticosteroid, hyaluronic acid and PRP in the last 3 months - Chronic use of medication with effect on the joint (e.g. corticoid) Exclusion criteria (not knee related) - Insufficient German language skills - Immunological diseases / autoimmune diseases / rheumatic disease - Age 70 years - BMI > 35 - Neurological diseases (e.g. Parkinson's disease, self-reported) - Major other lower extremity injuries / surgeries (e.g. insufficient cruciate ligaments) - Leg axis deviation > 15° (varus or valgus) - Breastfeeding or pregnant women - Dementia - Severe psychological disorder(s) - Alcohol abuse - Disseminated malignancy - Severe systemic disease - Hyperuricemia - Acute local or septic infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Knee Injury and Osteoarthritis Outcome Score (KOOS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain assessment using Visual Analog Scale (VAS) Amount of emergency medication used (ibuprofen 400mg) | — |
Countries
Germany
Contacts
Public ContactPaul Klein
Orthopädie im Mediapark MediaPark Klinik Köln
Outcome results
None listed