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Effects of Intermittent Hypoxia-Hyperoxia Training (IHHT) on Human Cardiac Performance, Characteristics and Function

Effects of Intermittent Hypoxia-Hyperoxia Training (IHHT) on Human Cardiac Performance, Characteristics and Function

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
DRKS
Registry ID
DRKS00028299
Enrollment
40
Registered
2023-05-16
Start date
2023-06-02
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Interventions

Group 1: Intervention group: 20 adults aged 50 and over. At the beginning, the following examinations / measurements are carried out: - cardiac echocardiography - Hypoxia tolerance test, max. 10 minut

Sponsors

Geriatrische Rehabilitation Oberbayern
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 90 Years

Inclusion criteria

Inclusion criteria: Adults, older than 50 years able to walk independently NYHA class not higher III

Exclusion criteria

Exclusion criteria: Excluded from this study are unstable patients with acute medical conditions, NYHA Class IV, the need for a left ventricular assist device, uncontrolled arrhythmias, COPD III – IV, previous intracerebral hemorrhage and arterial hypertension (systolic blood pressure [BP]. 180 mm Hg and/or or diastolic blood pressure. 100 mm Hg), as well as serious comorbidities such as cancer. Patients are also excluded if they are suffering from severe dementia (Mini-Mental State Examination (MMSE) test less than 12 points) or if the test persons cannot walk without the support of the staff.

Design outcomes

Primary

MeasureTime frame
After the last IHHT or placebo IHHT application, the tests are repeated from the beginning. This corresponds to the day before the patient is officially discharged after three weeks in rehabilitation. - Hypoxia tolerance test - cardiac echocardiography - Blood sample for analysis of biomarkers (conclusion of cardiac activity) - 6 MWT - Demmi - Time Up & Go - MMSE - DemTec - Short physical performance battery test - Moca test The chief doctor performs the echocardiography.

Secondary

MeasureTime frame
Improving the quality of life Cardiovascular disease remission The questionnaires and motor tests are administered by therapists and professionals after the last IHHT / placebo IHHT application.

Countries

Germany

Contacts

Public ContactAndreas Schmidt

Geriatrische Rehabilitation Oberbayern

a.schmidt@gro-med.de+49 (0) 8062 7014 0

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026