U07.1 J96.0
Conditions
Interventions
Group 1: Tidal volume centered approach:
Initiation of invasive mechanical ventilation will be performed when:
- PaO2/FiO2 ratio is below 150 and tidal volume exceeds 9.5 ml/kg predicted body weight
Sponsors
I. Medizinische Klinik, Universitätsmedizin Mannheim
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Written informed consent; Confirmed SARS-CoV-2 Infection; Moderate to severe ARDS (PaO2 / FiO2 < 200);
Exclusion criteria
Exclusion criteria: Currently pregnant; Participant with life expectancy of less than 6 months; Any medical contraindications or refusal by the individual or their legal representative to intubation and mechanical ventilation; Preexisting mechanical ventilation due to other conditions; Inability or unwillingness of individual or legal representative to give written informed consent.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Intubation rate, ventilator free days, number of required prone positiongs, need for ECMO | — |
Primary
| Measure | Time frame |
|---|---|
| Mortality | — |
Countries
Germany
Contacts
Public ContactSimon Lindner
I. Medizinische Klinik, Universitätsklinikum Mannheim
Outcome results
None listed