G35
Conditions
Interventions
Group 1: The number and interval of the study visits are based on the regular appointments that patients attend for guideline-compliant implementation of the therapies. As a rule, patients are seen at
Sponsors
Universitätsklinik für Neurologie, Evangelisches Krankenhaus Oldenburg Fakultät für Medizin und Gesundheitswissenschaften Carl von Ossietzky Universität
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: After this application has been approved, patients who present to the neurological university clinic at the Evangelical Hospital Oldenburg as inpatients and/or outpatients will be included. All participants have multiple sclerosis diagnosed according to the current McDonald criteria and are between 18 and 90 years old. Male and female subjects will be included. For subjects who are to be prospectively included in the study, a consent form must be available.
Exclusion criteria
Exclusion criteria: Patients under 18 years and over 90 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the detection of cellular and biochemical changes in correlation to disease activity and increase in clinical disability based on a worsening of the EDSS by at least 0.5 points. | — |
Secondary
| Measure | Time frame |
|---|---|
| As a secondary outcome, a comprehensive survey of neurological and neuropsychological tests will be used to create a sum score that is suitable and relevant for everyday life, and it will be investigated whether this can be correlated with the absolute level and a change in the EDSS. In addition, correlations of immunophenotyping, changes in immune cell activity and modifications in the (phospho-) lipid metabolism of people with MS with the level and change of the EDSS will be elicited. | — |
Countries
Germany
Contacts
Public ContactKarsten Witt
Universitätsklinik für Neurologie, Evangelisches Krankenhaus Oldenburg
Outcome results
None listed