I25.1 I25.13
Conditions
Interventions
Group 1: Acetylsalicylic acid 100 mg i.v. and metamizole 1g i.v. postoperatively with a time interval of 2 hours
Group 2: Acetylsalicylic acid 100 mg i.v. and metamizole 1g i.v. postoperatively at the
Sponsors
Klinik für Anästhesiologie, Universitätsklinikum Regensburg
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Adult patients undergoing aortocoronary bypass surgery who give their written consent to the study
Exclusion criteria
Exclusion criteria: - Minority - Pregnancy - Hypersensitivity to metamizole - Hypersensitivity to acetylsalicylic acid - Hypersensitivity to other ingredients of the medication used - Chronic pain treated with an NSAID - Hematopoietic disorders - above-average tendency to bleed - genetically determined glucose-6-phosphate dehydrogenase deficiency - Acute intermittent hepatic porphyria - Hypotension with unstable circulatory situation - acute gastrointestinal ulcers - Liver failure - Kidney failure - severe uncontrolled heart failure - Taking methotrexate at a dose of 15 mg or more per week
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Platelet function test from citrate blood recorded using Multiplate and thrombelastography (TEG 6S) at 6 defined time points: preoperative, 2 hours after surgery, on 1st + 2nd + 3rd + 7th postoperative day | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative analgesia, pain monitoring, cardiac enzymes, critical events | — |
Countries
Germany
Contacts
Public ContactSebastian Blecha
Universitätsklinikum Regensburg, Klinik für Anästhesiologie
Outcome results
None listed