M16.1 M17.1
Conditions
Interventions
Group 1: Group 1 (Therapy for 2-5 weeks)
Group 2: Group 2 (Therapy for 6-9 weeks)
Sponsors
Ludwig Boltzmann Gesellschaft, Ludwig Boltzmann Institute for Rehabilitation Research
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: • Planned unilateral knee or hip replacement for gonarthrosis. • Relatively painless and symptom-free contralateral lower extremity (no effusion, no load-limiting pain, VAS less than 5) • Age between 55 and 80 years • Good general health with good exercise capacity (defined by exclusion criteria) • Inclusion of men and non-childbearing women (postmenopausal and other reasons, to be confirmed by pregnancy test in case of doubt)
Exclusion criteria
Exclusion criteria: • Previous knee or hip arthroplasty • Body mass index (BMI) greater than 40 • Any conditions/states according to fresh leg vein thrombosis (shorter than 3 weeks), • Higher degree of joint effusion • infection • Pre-existing myopathy • Relevant neurological diseases with gait disturbance (Polyneuropathies, MB, Parkinson's) • Dementia / reduced cognitive abilities • Vestibular diseases with vertigo or balance disorders • Symptomatic cardiopulmonary disease in the past 6 months • Arterial hypertension not or insufficiently controlled by medication • Peripheral arterial occlusive disease (pAVK) • Malignant diseases • Rheumatic diseases and other internal contraindications • Other relevant functional impairment of the musculoskeletal system due to previous surgery, injury and degenerative diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Timed up and go test (TUGT) at five measurement time points. 2 weeks before surgery and 2, 6, 10 and 26 weeks after surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| 2 weeks before surgery and 2, 6, 10, and 26 weeks after surgery: • Pain in the joint at rest and on exertion (VAS). • Body composition (BIA) • Circumferential measurement of the lower extremity • Isokinetic force measurement in dynamometer • Stair climbing test • 10m walk test • Range of motion (ROM) of the affected and unaffected joint • Questionnaire EQ5, HAQ, SAF, WOMAC • Blood samples • Saliva samples Optional on volunteers 2 weeks before surgery and 10 weeks after surgery: • Muscle biopsy M. quadriceps | — |
Countries
Austria, Slovakia
Contacts
Public Contact; ;
Ludwig Boltzmann Gesellschaft, Ludwig Boltzmann Institute for Rehabilitation Research;Univerzita Komenského v Bratislave,Fakulta telesnej výchovy a športu
Outcome results
None listed