TINNITUS
Conditions
Interventions
Group 1: All patients get blood drawn before and after the first hyperbaric oxygen therapy, as well as after the fifth and after the tenth therapy. Also, urine samples are given by all patients before
Sponsors
HBO-Zentrum Euregio Aachen
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: HBO therapy in the context of a hearing loss/ tinnitus - No known previous kidney diseases - No known vascular diseases - GFR > 90m/min (via CKD-EPI) - No use of permanent medication with influence on renal function - Sufficient knowledge of German
Exclusion criteria
Exclusion criteria: - GFR < 90ml/min - Diseases with limitation of endocrine and exocrine renal function - Known intolerance to high ambient pressures with inability to equalize pressure (via Valsalva maneuver). Exclusion is based on patient history and symptoms. - Diseases of the middle ear - claustrophobia - Pulmonary disorders, such as severe bronchial asthma, emphysema, pneumothorax, acute infectious diseases - Acute upper respiratory tract and/or sinus infections with sinunasal congestion ("stuffy nose" or rhinitis) - Non-removable implants such as pacemakers, drug pumps, breast implants depending on manufacturer's instructions - Pregnancy and lactation - Severe cardiovascular diseases, in particular uncontrolled or poorly controlled arterial hypertension or heart failure - Sickle cell anemia - Condition following surgical procedures on the chest, ear or eye - seizure disorders - Taking medications that lower the seizure threshold (e.g., antidepressants) - Persistent foramen ovale (PFO) - Known vascular diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoints will be measured using laboratory analysis of blood and urine samples. The primary endpoints are: 1.Hyperbaric oxygen therapy causes adjustments in renal metabolism that can be detected by urinary parameters. 2.Repeated hyperbaric oxygen therapy induces responses in the body that resemble intermittent hypoxia. | — |
Secondary
| Measure | Time frame |
|---|---|
| The following secondary hypotheses are put forward: 1. even single hyperbaric oxygen therapy has a detectable effect on metabolic adaptations of the kidney. 2. repeated hyperbaric oxygen therapy stimulates hematopoietic processes, primarily Erythropoetin formation. | — |
Countries
Germany
Contacts
Public ContactUllrich Siekmann
HBO-Zentrum Euregio Aachen
Outcome results
None listed