Impact of lidocain administration on hemodynamics during anesthesia

Impact of lidocain administration on hemodynamics during anesthesia - FLOW

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00028101

Enrollment

10000

Registered

2022-02-11

Start date

2025-06-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

5-65 Operationen am Ovar 5-66 Operationen an der Tuba uterina 5-67 Operationen an der Cervix uteri 5-68 Inzision, Exzision und Exstirpation des Uterus 5-69 Andere Operationen am Uterus und Operationen an den Parametrien 5-70 Operationen an Vagina und Douglasraum 5-71 Operationen an der Vulva 5-87 Exzision und Resektion der Mamma 5-88 Andere Operationen an der Mamma

Interventions

Group 1: female patients (= 18 years) undergoing specific gynaecological surgery under general anesthesia: with intraoperative, intravenous lidocaine administration Group 2: female patients (= 18 year

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: > age = 18 years > female sex > ASA-Score I to III > specific gynecological surgery under general anesthesia (see section health condition/problem) > surgery between 01.01.2013 to 31.12.2021

Exclusion criteria

Exclusion criteria: > ASA-Score IV and V > heart pacemaker > known allergy to local anesthetics

Design outcomes

Primary

Measure	Time frame
Differences in cumulative duration of intra- and postoperative bradycardic episodes[1] (normalized to duration of surgery and time in recovery room/PACU) between patients with vs without intravenous lidocaine administration [1] heart rate < 55 beats per minute	—

Secondary

Measure	Time frame
Differences between patients with vs. without intravenous lidocaine administration in the intraoperative and postoperative periods (duration of surgery and time in recovery room/PACU) with respect to: > the cumulative duration of hypotensive episodes[2] > use of catecholamines (adrenaline, noradrenaline, dopamine) > use of antiarrhythmic medication (including atropine) > analgesic requirements > antiemetic needs > resuscitation > intraoperative death > time from induction to withdrawal of anesthesia [2] systolic blood pressure < 100 mmHg and/or mean arterial blodd pressure < 60 mmHg	—

Measure

Time frame

Differences between patients with vs. without intravenous lidocaine administration in the intraoperative and postoperative periods (duration of surgery and time in recovery room/PACU) with respect to: > the cumulative duration of hypotensive episodes[2] > use of catecholamines (adrenaline, noradrenaline, dopamine) > use of antiarrhythmic medication (including atropine) > analgesic requirements > antiemetic needs > resuscitation > intraoperative death > time from induction to withdrawal of anesthesia [2] systolic blood pressure < 100 mmHg and/or mean arterial blodd pressure < 60 mmHg

—

Countries

Germany

Contacts

Public ContactPhilipp Baumbach

Klinik für Anästhesiologie und Intensivmedizin Universitätsklinikum Jena

Philipp.Baumbach@med.uni-jena.de+49-3641-9-325798

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026