The determination of CRP, IL-6 and blood culture from the umbilical cord vein in premature babies - a valid alternative to blood collection from the child's vein?

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00028077

Enrollment

Registered

2022-02-09

Start date

2022-03-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prematurity

Interventions

Group 1: Determination of CRP, IL6 and blood culture from umbilical vein blood and fetal blood immediately postnatally.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Premature infants < 35+0 weeks of gestation and consent of both parents

Exclusion criteria

Exclusion criteria: Withdrawal of study consent by the patient parents

Design outcomes

Primary

Measure	Time frame
The significance of the difference between the determined parameters (CRP, IL-6 and blood culture) from infant blood and the determined parameters from umbilical vein blood is the primary outcome of this study. The determination is made immediately postnatally by taking blood from the umbilical vein and from the child's vein. From a case number of approx. 65, one could already distinguish a correlation (intraclass) of 0.9 from a correlation of only 0.8 with 90% power.	—

Measure

Time frame

The significance of the difference between the determined parameters (CRP, IL-6 and blood culture) from infant blood and the determined parameters from umbilical vein blood is the primary outcome of this study. The determination is made immediately postnatally by taking blood from the umbilical vein and from the child's vein. From a case number of approx. 65, one could already distinguish a correlation (intraclass) of 0.9 from a correlation of only 0.8 with 90% power.

—

Secondary

Measure	Time frame
Does the result of diagnostics from umbilical cord vein blood change the therapeutic procedure?	—

Countries

Germany

Contacts

Public ContactJuliane Tautz

Uniklinik Düsseldorf, Klinik für Allgemeine Pädiatrie, Neonatologie und Kinderkardiologie

juliane.tautz@med.uni-duesseldorf.de0211-8117716

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026