F06.7 F01
Conditions
Interventions
Group 1: Patients with a mild cognitive disorder
Patients will be tested with the following test battery:
- Digit Span from the WAIS-IV
- CERAD-NP-Plus Test battery
- Farbe-Wort-Interferenztest from
Sponsors
Bergische Universität Wuppertal,Lehrstuhl für Allgemeine und biologische Psychologie
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: All participants must be between 65 and 85 years old and have normal or corrected to normal vision. Controls must score more than 27 points in the mini-mental state examination (MMSE), have no memory deficit in the CERAD-NP (Ehrensperger et al., 2010). To exclude moderate and severe dementia cases, all patients must score at least 20 points in the MMSE (Deutsche Gesellschaft für Psychiatrie und Psychotherapie, Psychosomatik und Nervenheilkunde e.V. (DGPPN) & Deutsche Gesellschaft für Neurologie e.V. (DGN), 2016). Additionally, VCI and MCI patients must have a psychometrically proven memory impairment, either in the Rey’s auditory verbal learning test (Helmstaedter et al., 2001) or CERAD-NP (Ehrensperger et al., 2010) thus achieving a standard score between 1,5 and 3 standard deviations below the norm group average (Strauss et al., 2006). Further, VCI patients must also have a Hachinski-Score > 6. The MCI group must have a Hachinski-Score < 5.
Exclusion criteria
Exclusion criteria: Patient controls must not be classified as depressed according to the geriatric depression scale (Gauggel & Birkner, 1999). They also are not allowed to have a neurological disorder affecting the central nervous system, such as epilepsy, stroke, Parkinson’s Disease or any dementia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The participants will have to memorize a number of words from a study list of 80 words, that differ in the degree of their semantic relatedness, which is defined as the number of cooccurrences in the lexicon (Hofmann et al., 2011). In the following recognition task, the participants will have to decide, if the presented word was in the study list or if it is new (80 new words). The distractor words either cooccur often or rarely with the words from the study list. Thus, two within subject factors are formed and manipulated – Oldness (old vs. new words) and Cooccurrence frequency (high vs. low). The third experimental factor is the participant group (MCI, VCI, C). After the recognition trial the participants will be asked to recall as many words as possible from all of the presented words (study and distractor words). The experimental task duration is about 35 Minutes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Data Analyses Data will be analyzed using the conjunction of the AROM model (Hofmann et al., 2011) and a decision model, e.g. two non-linear competing accumulators (Usher & McClelland, 2001) using an approximate Bayesian computation differential evolution monte-carlo algorithm (Turner et al., 2013; Turner & Sederberg, 2012). Statistical Analyses The recovered parameters and summary statistics will then be analyzed in a linear mixed effects model. | — |
Countries
Germany
Contacts
Public ContactLeo Sokolovic
Helios Universitätsklinikum Wuppertal
Outcome results
None listed