H40.1
Conditions
Interventions
Group 1: After enrolment in the study, participants will stay in the DLR research bed rest facility for 3 days
and 2 nights. There will be a 50:50 randomization in two groups as a cross over design.
Sponsors
DLR, Institut für Luft- und Raumfahrtmedizin(German Aerospace Center, Institute of Aerospace Medicine) Klinische Luft- und Raumfahrtmedizin
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patients with ocular hypertension, primary open-angle glaucoma or secondary openangle glaucoma with pigment dispersion glaucoma and pseudoexfoliation glaucoma with or without topical antiglaucoma drugs. - Verified nocturnal peeks in intraocular pressure in lying position in comparison with values of intraocular pressure at day in at least one eye (5 mmHg on average). - Consent to participating in this study. - Ability to understand the patient information and study procedures and to give consent or consent given by an independent guardian of the patient to participate in this study.
Exclusion criteria
Exclusion criteria: - Inability to lay in bed for 6 hours without getting up. - Spinal cord diseases - Other forms of glaucoma than the ones specified above - Previous Glaucoma surgeries (exceptions: cataract surgery, surgery of the trabecular meshwork, SLT) - Missing willingness and consent to participate in the study - Allergy against eye drops especially local anaesthetic eye drops - Diabetes mellitus - No other medical conditions that need treatment during the study period besides medical treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Endpoint: A decrease of intraocular pressure (IOP) of > 3 mm Hg in nocturnal upper body and head up tilt of +10° compared to normal sleeping position. | — |
Secondary
| Measure | Time frame |
|---|---|
| A decrease in blood pressure of > 10% of the daily mean systemic blood pressure and a change in choroidal blood patter. | — |
Countries
Germany
Contacts
Public ContactClaudia Stern
DLR, Institut für Luft- und RaumfahrtmedizinKlinische Luft- und Raumfahrtmedizin
Outcome results
None listed