This study includes a non-pharmacological lifestyle-intervention for elderly persons, which is conducted within the scope of cognitive decline.ICD-10 CM: Age-related cognitive decline: R41.81
Conditions
Interventions
Group 1: Sport intervention (specific intervention group)
Multicomponent aerobic and coordination training
Duration: 8 weeks
Contents:
- 3 to 4 times / week: continuous walking or interval units (25
Sponsors
Universitätsklinikum Jena
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: - Healthy - 60-75 years old - Owning a smartphone - full immunization against SARS-CoV-2 - PC or tablet with internet access
Exclusion criteria
Exclusion criteria: - relevant, uncorrected vision disorder - relevant physical impairment - relevant pre-existing psychiatric or neurological condition (e.g. major depression, focal structural brain damage, stroke, epilepsy) - evidence of cognitive decline in ACE-III (Score = 86) - permanent sedative medication - general contraindication for MRI (pacemaker, artificial heart valve, unremovable metal pieces in/at body) - loss of ability to give consent - relevant systemic diseases: cancer, severe kidney or liver disease, type 1 or 2 diabetes, diseases with intrinsic inflammation activity (e.g. Crohn's disease, asthma, rheumatic arthritis) - chronic infection (e.g. HIV, active tuberculosis) - any kind of infectious disease, stadium 3 or 4 heart disease, cardiovascular disease - chronic constipation or diarrhoea - treatments which influence glucose metabolism or microbiome - antidiabetics - laxatives - antibiotics, antifungal or antiviral treatment (in the last 3 months)) - treatment with glucocorticoids - treatment with immunsuppressives (cortison, cortison-like and artificial immunsuppressives) - weight reducing medicine (last 2 months) - symptoms/clinical markers of an infection (last month) - excessive alcohol abuse (women >40g, men>80g /day) or drug abuse - alcohol or drug abuse in the past - severe eating disorder - disturbance of the iron balance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parameter visual processing speed C (in items per second), measured with a psychophysical whole report and computational modelling on the basis of the theory of visual attention (TVA) (Bundesen, 1990) For further information, see: Finke et al., 2010 & Penning et al., 2021 Bundesen, C. (1990). A theory of visual attention. Psychological Review, 97(4), 523–547. https://doi.org/10.1037/0033-295x.97.4.523 Finke, K., Dodds, C.M., Bublak, P. et al. Effects of modafinil and methylphenidate on visual attention capacity: a TVA-based study. Psychopharmacology 210, 317–329 (2010). https://doi.org/10.1007/s00213-010-1823-x Penning, M. D., Ruiz-Rizzo, A. L., Redel, P., Müller, H. J., Salminen, T., Strobach, T., ... & Finke, K. (2021). Alertness training increases visual processing speed in healthy older adults. Psychological science, 32(3), 340-353. | — |
Secondary
| Measure | Time frame |
|---|---|
| All tests that are listed below will be conducted before the intervention (T1) as well as right after the intervention (T2). Find the test instrument/method of assessment in parentheses behind the outcome. Cognition: - Capacity of the visual short-term memory K (TVA) - Efficiency of top-down control (TVA) - Cognitive screening (Addenbrooke's Cognitive Examination III (ACE-III)) - Memory (Rey-Osterrieth Complex Figure Test (ROCF) + Verbaler Lern- und Merkfähigkeitstest (Verbal and Learning Memory Test, VLMT)) - Inhibition ability (Stroop test: Farbe-Wort-Interferenztest (Color-Word-Interference Test, FWIT) Version Günther Bäumler) - processing speed (Trail Making Test A, paper pencil & virtual reality version) - Executive control (Trail Making Test B, paper pencil & virtual reality version) - General intelligence (Mehrfachwahl-Wortschatz-Intelligenztest (Multiple Choice Vocabulary Intelligence Test; MWT-B)) Brain function and -structure: Magnet-Resonance-Tomography for: - Indicator of biological brain age: BrainAGE score - resting state network connectivity - structural connectivity - individual neuromorphology - inflammation markers Gut-brain-barrier function: Blood and fecal-sample for: - Blood and plasma marker for bacterial translocation: Lipopolysaccharide binding protein (LBP) and zonulin - inflammation markers - calprotectin - microbiome composition - transcriptome, metabolome Cardio-respiratory fitness: - (Estimate) of maximum oxygen uptake (VO2max) (questionnaire Garnvik et al., 2019*) - Distance of 6 min walking test - Physical activity behaviour (Personal Activity Intelligence, PAI) - Sleep-, recovery- and activity-behavior (by daily questionnaire Immunological Inventory for recovery and activity (II-EBZ)) *GARNVIK, L. E., MALMO, V., JANSZKY, I., WISLØFF, U., LOENNECHEN, J. P. & NES, B. M. (2019). Estimated Cardiorespiratory Fitness and Risk of Atrial Fibrillation: The Nord-Trøndelag Health Study. Medicine & Science in | — |
Countries
Germany
Contacts
Public ContactSimon Schrenk
Universitätsklinikum Jena, Hans-Berger-Klinikum für Neurologie
Outcome results
None listed