moderate depressive episode, severe depressive episode
Conditions
Interventions
Group 1: Group of patients receiving a boostered medical consultation.
Group 2: Group of patients gives their usual informed consent.
Sponsors
LVR-Klinikum Essen
Eligibility
Sex/Gender
All
Age
18 Years to 69 Years
Inclusion criteria
Inclusion criteria: o Age from 18 to 69 years o moderate or severe depressive episode (according to Hamilton Rating Scale for Depression, HDRS) o at least 2 unsuccessful antidepressant medication attempts in the history of the current episode
Exclusion criteria
Exclusion criteria: o Incapacitated persons and persons in official or judicial custody. o Persons with consumptive diseases and/or in poor general condition o No sufficient hearing or reading ability o Contraindications for rTMS presence of ferromagnetic material (e.g. cochlear implants) in the brain Pregnancy Cardiac pacemaker Epilepsy o previous rTMS treatment o electroconvulsive therapy in the preceding 6 months o relevant structural lesions on MRI: this excludes expected age-related changes such as mild cerebral microangiopathy in patients over 50 years of age or changes without expected relevance such as small arachnoid cyst o Relevant comorbidities Current substance abuse or dependence Organic mental disorders Dementia Schizophrenia and schizoaffective disorder Neurological disorders, e.g., multiple sclerosis, Parkinson's syndrome (excluding headache disorders) Diseases that are associated with an inflammatory response and lead to permanently elevated inflammatory parameters Severe internal diseases associated with a significantly reduced general condition
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Therapy success. Measurement: questionnaires. | — |
Secondary
| Measure | Time frame |
|---|---|
| therapy success. Measurement: cognitive tests, MRI, blood sampes, salive samples | — |
Countries
Germany
Contacts
Public ContactKatharina Marie Steiner
LVR-Klinikum Essen
Outcome results
None listed