I50.9
Conditions
Interventions
Group 1: Heart failure group:
pupillometric examinations with a hand-held pupillometer (PLR-3000) and an eye tracker (Eyelink 1000 Plus),
cognitive stress (reproducing series of numbers),
Determinatio
Sponsors
Immanuel Klinikum Bernau Herzzentrum Brandenburg Universitätsklinikum der MHB
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Target group: Adult inpatients of the cardiology department of the Heart Centre Brandenburg, Immanuel Klinikum Bernau with acute "de novo" heart failure or acute decompensation of chronic heart failure ("acute decompensated chronic heart failure") and a written informed consent to participate in the study. Control group: A parallel group of adults, matched for age and sex, without acute de novo heart failure or acute decompensated chronic heart failure, with written informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: Individuals with a history of eye surgery or diseases that may affect pupillary function (e.g. severe retinopathy), patients who are unable to follow the representations on the computer screen during the eye tracking study due to poor visual acuity, and patients who are unable to understand the scope and content of the study to provide written informed consent to participate in the study will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Combined endpoint of cardiac events within 1 year after index hospitalisation (myocardial infarction, stroke, rehospitalisation within 90 days due to de novo /acute decompensated heart failure and cardiovascular mortality) | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are the parameters included in the combined endpoint, 1-year all-cause mortality and incidence of heartburn/stomach ulcer . Other endpoints include changes in pupil size, pupillary light reflex, microsaccade rate and amplitude, and working memory capacity. | — |
Countries
Germany
Contacts
Public ContactAnja Haase-Fielitz
Immanuel Klinikum Bernau Herzzentrum Brandenburg Universitätsklinikum der MHB
Outcome results
None listed