Detection of liver dysfunction and coagulation failure in severely burned patients using non-invasive monitoring (LiMON®, FA Getinge)

Detection of liver dysfunction and coagulation failure in severely burned patients using non-invasive monitoring (LiMON®, FA Getinge) - Delico

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00027883

Enrollment

Registered

2022-08-05

Start date

2022-09-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K72.0 T29-T32

Interventions

Group 1: The data collected during the course of treatment with the LiMON should be compared with the classic markers of liver function and damage (transaminases, cholestasis parameters, cholinesteras

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: – mindestens eine operative Versorgung im stationären Verlauf – Alter > 18 Jahre – Erstversorgung in Allgemeinanästhesie unter kontrollierter Beatmung 202 / 5 000 Fordítási találatok – Burn > 30% body surface, grade II-IV – at least one surgical treatment during the inpatient course – Age > 18 years – First aid in general anesthesia with controlled ventilation

Exclusion criteria

Exclusion criteria: – pregnancy – Age < 18 years – Refusal to participate in the study by patients or carers or survivors – TEN/Lyell syndrome – Primary palliative therapy concept

Design outcomes

Primary

Measure	Time frame
The aim of the study is to investigate the correlation of ICG-PDR, classic laboratory diagnostic markers of liver synthesis and parameters of hemostasis The data collected during the course of treatment with the LiMON should be compared with the classic markers of liver function or damage (transaminases, cholestasis parameters, cholinesterase, total protein, etc.) that occur in the routine course of treatment. In addition, it is planned to change the previous diagnostic routine processes to systematically supplement a more intensive recording of haemostaseological changes and to correlate them with the ICG-PDR and with the classical laboratory chemistry. The hemostasis characterization should at least include: aPTT, INR, D-dimer, fibrinogen, antithrombin, factor XIII, protein C, protein S, factors II, V, VII, VIII, IX, X and thromboelastometry (ROTEM®) Based on the above investigations, a relation to the clinical course of the burn injury is to be analysed.	—

Measure

Time frame

The aim of the study is to investigate the correlation of ICG-PDR, classic laboratory diagnostic markers of liver synthesis and parameters of hemostasis The data collected during the course of treatment with the LiMON should be compared with the classic markers of liver function or damage (transaminases, cholestasis parameters, cholinesterase, total protein, etc.) that occur in the routine course of treatment. In addition, it is planned to change the previous diagnostic routine processes to systematically supplement a more intensive recording of haemostaseological changes and to correlate them with the ICG-PDR and with the classical laboratory chemistry. The hemostasis characterization should at least include: aPTT, INR, D-dimer, fibrinogen, antithrombin, factor XIII, protein C, protein S, factors II, V, VII, VIII, IX, X and thromboelastometry (ROTEM®) Based on the above investigations, a relation to the clinical course of the burn injury is to be analysed.

—

Countries

Germany

Contacts

Public ContactMarianne Kruse

Klinik für Anästhesiologie, Intensiv- und Schmerzmedizin

Marianne.Kruse@ukb.de0305681-3102

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026