Pain in healthy people
Conditions
Interventions
Group 1: Healthy participants receive either moderate-to-high or no tonic (long-lasting) pain as a conditioning stimulus in a conditioning pain modulation paradigm (within-subjects conditions).
Sponsors
Institut für Systemische Neurowissenschaften, Universitätsklinikum Hamburg-Eppendorf
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Healthy, body mass index 18-30, fulfills MRI safety criteria
Exclusion criteria
Exclusion criteria: Left-handed, restlessness/cannot lie still for a long time, pregnant or nursing, acute or chronic pain in the arm(s), acute or chronic somatic or psychiatric illness (based on self-disclosure or professional examination), regular medication intake (except for allergy or thyroid medication, contraceptive medication, occasional use of pain medication), intake of painkillers in the 24 hours preceding the study appointment, intensive sport on the day of the study appointment, symptoms of respiratory illness, contact with a Covid-19 case in the last 14 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of the study is to investigate the neural correlates of conditioned pain modulation simultaneously in the brain and the spinal cord. Primary outcomes to observe: Change in blood-oxygen-level-dependent (BOLD) response to phasic (fast, repeated) test stimuli during painful vs. non-painful tonic pressure stimuli; change in subjective painfulness ratings on a visual analogue scale (VAS) to phasic (fast, repeated) test stimuli during painful vs. non-painful tonic pressure stimuli. | — |
Secondary
| Measure | Time frame |
|---|---|
| Exploratory analyses: 1) Functional connectivity between the brain regions of the descending pain modulatory system, 2) Changes in skin conductance responses. | — |
Countries
Germany
Contacts
Public ContactChristian Büchel
Institut für Systemische Neurowissenschaften, Universitätsklinikum Hamburg-Eppendorf
Outcome results
None listed