E11
Conditions
Interventions
Group 1: Participation in morning training (bicycle ergometer training), three times a week on non-consecutive days, alternating between high-intensity interval training and moderate training (60-70%
Sponsors
DLR - Institut für Luft- Und RaumfahrtAbteilung für für Muskel- und Knochenstoffwechsel
Eligibility
Sex/Gender
All
Age
30 Years to 69 Years
Inclusion criteria
Inclusion criteria: Type 2 diabetes diagnosis according to ADA criteria, not physically active (<1 h of structured exercise per week), BMI between 19 and 35 kg/m2 ), male and female sex, capacity to consent, aged 30 to 69 years of age
Exclusion criteria
Exclusion criteria: Weight fluctuations of more than 10% within the last 6 months, therapy with glitazones, betablockers or insulin, peripheral artery occlusive disease IV, venous thromboembolic events, existing or past foot ulcers, electrocardiogram abnormalities (alterations of the ST segment, higher-grade arrhythmia), unstable angina pectoris, uncontrolled hypertension, heart-, renal-and liver-failure (NYHA =II, serum creatinine =1.6 mg/dl, Aspartate-Aminotransferase/ Alanine-Aminotransferase/Gamma-Glutamyltransferase), Claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Average 24 h glucose (mg/dl) from continuous glucose monitoring | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of glucose metabolism: glucose, insulin and glucagon concentrations Changes of lipid metabolism: chylomicrons, VLDL, HDL, TG concentrations Peripheral and hepatic insulin sensitivity Characterization of postprandial glucose metabolism using stable isotope 13C-glucose tracer Adipose tissue: adipocyte size and inflammatory status Mitochondrial function in skeletal muscle and adipose tissue Body composition Aerobic performance and muscle strength Energy turnover and substrate utilization Expression of clock genes and proteomics of skeletal muscle Metabolite analysis of plasma, muscle and adipose tissue | — |
Countries
Germany
Contacts
Public ContactDominik Pesta
DLR - Institut für Luft- und Raumfahrt
Outcome results
None listed