Investigation into the protective effects of apple juice on the intestinal barrier in athletes

Investigation into the protective effects of apple juice on the intestinal barrier in athletes - UPEADS

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00027860

Enrollment

Registered

2022-08-18

Start date

2022-01-14

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

no deseases are investigated healthy volunteers

Interventions

Group 1: Control group - after endurance exercise they receive 500ml of water Group 2: Control group 2: receive 500ml soft drink after endurance exercise Group 3: Intervention group: receive 500ml of

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: healthy endurance athletes with an age of 18-60 years

Exclusion criteria

Exclusion criteria: Hormone substitution; incl. thyroid Hormone therapy Smokers One-sided diet (e.g. vegan) People in need of treatment Cardiac arrhythmia Heart failure (EF<55) Performance-limiting pAVK (Fontaine stage = II) Performance- or training-limiting degenerative joint diseases or muscular diseases Performance-limiting kidney disease Performance-limiting neurological disease oncological diseases in the history (< 5 years) Psychiatric and/or addictive disorders

Design outcomes

Primary

Measure	Time frame
9ml venous blood sampling at the time points: T0 (start of examination day), T1 (immediately after physical exercise), T2 (+40 min after beverage consumption), T3 (+80 min after beverage consumption), T4 (+120 min after beverage consumption), T5 (+180 min after beverage consumption), T6 (24h after beverage consumption). The following parameters should be examined: Intestinal fatty acid-binding proteins (I-FABP), zonulin, lipopolysaccharide binding protein (LBP), bacterial endotoxin, determination of toll-like receptors in isolated peripheral mononuclear cells (PBMC), interleukin 6 and 10 (IL 6, IL 10), macrophage migration inhibitory factor (MIF), oxidative stress; creatine kinase (CK) and myoglobin; lactate (measurement at T1).	—

Measure

Time frame

9ml venous blood sampling at the time points: T0 (start of examination day), T1 (immediately after physical exercise), T2 (+40 min after beverage consumption), T3 (+80 min after beverage consumption), T4 (+120 min after beverage consumption), T5 (+180 min after beverage consumption), T6 (24h after beverage consumption). The following parameters should be examined: Intestinal fatty acid-binding proteins (I-FABP), zonulin, lipopolysaccharide binding protein (LBP), bacterial endotoxin, determination of toll-like receptors in isolated peripheral mononuclear cells (PBMC), interleukin 6 and 10 (IL 6, IL 10), macrophage migration inhibitory factor (MIF), oxidative stress; creatine kinase (CK) and myoglobin; lactate (measurement at T1).

—

Secondary

Measure	Time frame
Stool sampling (Art. No. (PZN): 4865079) Microbiota examination by means of 16 S amplicon analysis	—

Countries

Germany

Contacts

Public ContactPatrick Diel

Deutsche Sporthochschule Köln, Institut für Kreislaufforschung und Sportmedizin, Abteilung 2 Molekulare und zelluläre Sportmedizin - Zentrum für präventive Doping Forschung

diel@dshs-koeln.de022149825540

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026