Sphingosine 1-phosphate (S1P) mediated adaptations to hypoxemic conditions in red blood cells (RBC) in acute and chronic respiratory diseases

Sphingosine 1-phosphate (S1P) mediated adaptations to hypoxemic conditions in red blood cells (RBC) in acute and chronic respiratory diseases - MetRBC study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00027837

Enrollment

240

Registered

2024-05-06

Start date

2024-01-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute and chronic pulmonary disease

Interventions

Group 1: Not interventional

Patients with acute and chronic respiratory diseases as well as those with Long-COVID-19 are being recruited. A healthy control will be recruited as well.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Acute respiratory disorder, Chronic respiratory disorder, COVID-19 post-recovery, healthy Participants

Exclusion criteria

Exclusion criteria: Lack of consent; Patients included in intervention studies; Patients < 18 years old; Moribund status

Design outcomes

Primary

Measure	Time frame
Metabolic changes in erythrocytes Patients vs. controls. S1P concentration in erythrocytes, serum, plasma and S1P enzyme and other metabolic metabolites plus erythrocyte function.	—

Secondary

Measure	Time frame
Severity of the illness and course of the illness.	—

Countries

Germany

Contacts

Public ContactMartin Winkler

Universitätsmedizin Göttingen

martin.winkler@med.uni-goettingen.de+49551390

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026