Variability in muscular adaptation to strength training: Intra- and inter-individual differences in the adaptation reactions of the skeletal muscles to a maximum strength training load with increased eccentric load compared to the conventional maximum strength load

Variability in muscular adaptation to strength training: Intra- and inter-individual differences in the adaptation reactions of the skeletal muscles to a maximum strength training load with increased eccentric load compared to the conventional maximum strength load - VarKra

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

DRKS

Registry ID

DRKS00027803

Enrollment

Registered

2022-01-20

Start date

2022-02-14

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Strength training

Interventions

Group 1: Maximum strength training with eccentric overload (leg extension) Group 2: Conventional concentric/eccentric maximum strength training (leg extension)

Eligibility

Sex/Gender

Male

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: healthy non-professional athletes; regular training (at least 3x/week), including strengh training 1-2x/week

Exclusion criteria

Exclusion criteria: Lack of understanding of language and thus lack of opportunity for enlightenment; missing written declaration of consent; diseases (abnormalities) of the musculoskeletal system such as arthrosis, spondylarthrosis, joint or spinal deformity; history of hypersensitivity to local anesthetics; cardiovascular disease (e.g. hypertension, coronary heart disease, hemodynamically relevant valve defects, high-grade cardiac arrhythmia); any acute or chronic illness (e.g. infectious diseases); disruption of coagulation activity; history of muscle disease; regular use of medication, especially non-steroidal anti-inflammatory drugs; use of creatine supplements

Design outcomes

Primary

Measure	Time frame
In the planned project, it is to be investigated whether an intensive concentric/eccentric strength training load of the leg extensors with increased eccentric load (CON/ECC+) causes an increased activation, proliferation and differentiation of satellite cells than an intensive conventional concentric/eccentric strength training load (CON/ECC). In order to avoid the effects of inter-individual variability, the effects of both strength training methods on both legs of one and the same test subject are to be examined at the same times.	—

Measure

Time frame

In the planned project, it is to be investigated whether an intensive concentric/eccentric strength training load of the leg extensors with increased eccentric load (CON/ECC+) causes an increased activation, proliferation and differentiation of satellite cells than an intensive conventional concentric/eccentric strength training load (CON/ECC). In order to avoid the effects of inter-individual variability, the effects of both strength training methods on both legs of one and the same test subject are to be examined at the same times.

—

Secondary

Measure	Time frame
Characteristics are to be identified that allow a prediction of the extent of the reactions to an exhausting training stimulus and the course of regeneration.	—

Countries

Germany

Contacts

Public ContactAnne Quermann

Universitätsklinikum Heidelberg, Medizinische Klinik, Innere Medizin VII: Sportmedizin

anne.quermann@med.uni-heidelberg.de062215638192

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026