Effect of cardiac contractility modulation on the longitudinal strain in patients with chronic heart failure (CCM strain)

Effect of cardiac contractility modulation on the longitudinal strain in patients with chronic heart failure (CCM strain) - CCM

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

DRKS

Registry ID

DRKS00027533

Enrollment

Registered

2021-12-29

Start date

2022-01-02

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I50.9

Interventions

Group 1: Patients after immediate CCM (cardiac contractility modulation) implantation, 14 days after inclusion in the study Group 2: Patients after delayed CCM (cardiac contractility modulation) impla

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: - Age> 18 years - Limited LV-EF (25-45%) - guideline-based drug treatment of chronic heart failure - clinical indication for the use of cardiac contractility modulation (CCM) - written declaration of consent

Exclusion criteria

Exclusion criteria: - lack of consent to participate in the study - Interventional or surgical heart procedure planned within the next 3 months (e.g. PCI, bypass surgery, treatment of a heart valve defect or a structural heart defect) - Inability to evaluate cardiac function by echocardiography - no possibility for a follow-up examination (3-month check-up)

Design outcomes

Primary

Measure	Time frame
CCM implant in situ? (1: yes; 2: no) mean daily CCM therapy duration (h) NYHA stage (1 to 4) Heart attack (1: yes; 2: no) Stroke (1: yes; 2: no) Hospitalization due to Heart failure (1: yes; 2: no) unplanned hospitalization of any cause (1: yes; 2: no) PCI / catheter intervention / heart surgery other than CCM implantation that has taken place since randomization ((1: yes; 2: no) Death (1: yes; 2: no)	—

Measure

Time frame

CCM implant in situ? (1: yes; 2: no) mean daily CCM therapy duration (h) NYHA stage (1 to 4) Heart attack (1: yes; 2: no) Stroke (1: yes; 2: no) Hospitalization due to Heart failure (1: yes; 2: no) unplanned hospitalization of any cause (1: yes; 2: no) PCI / catheter intervention / heart surgery other than CCM implantation that has taken place since randomization ((1: yes; 2: no) Death (1: yes; 2: no)

—

Secondary

Measure	Time frame
cancellation	—

Countries

Germany

Contacts

Public ContactCornelia Raab

Katholisches Krankenhaus Erfurt

raab.cornelia@kkh-erfurt.de03616541813

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026