ICD-10-CM: J45.990 Exercise-induced asthma ICD-10-CM: J00.J99 Diseases of the respiratory system: (Small-airways-disease) I20-I25
Conditions
Interventions
Group 1: Healthy high-performance athletes, intervention = spiroergometry
(at least 18 yrs old, exercise-load greater than 10h/ week)
Group 2: Healthy control group
(ageajusted and sexajusted stude
Sponsors
Universitätsklinikum Schleswig Holstein, Medizinische Klinik III (Pulmologie)
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1) Minimum age 18 years old 2) BMI-20-27,5kg/m² 3) No pre-existing diseases 4) Nonsmoker 5) High-performance athletes: sport, more than 10h exercise load per week 6) Control-group: less than 3h exercise per week and no prior exercise of high-performance sports 7) Written consent of the study-protocol 8) Exclusion of pregnancy, respectively hormonal contraception
Exclusion criteria
Exclusion criteria: 1) Musculoskeletal diseases that make the execution of a spiroergometry impossible 2) Acute viral or bacterial infectious diseases 3) Any diseases that might pose a threat to the subject while being stressed physically 4) Severe dysrhythmia, heart deficiency 5) Pregnancy 6) Drug abuse 7) Participation in another drug study 8) Lack of compliance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint is the expected increase of pulswave-velocity 15 minutes after the workout in both groups. Hypothesis I: After a workout up to their maximum physical ability subjects in both groups show an increased pulswave-velocity as a sign of blood-vessel-damage. Null-hypothesis: After a workout up to their maximum physical ability subjects in both groups do not show an increased pulswave-velocity. Physical stress up to the individuals maximum physical ability does not lead to an increased pulswave-velocity as a sign of blood-vessel-damage, neither in high-performance athletes, nor in not-high-performance athletes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are the comparisons of both groups for parameters of peripheral and central haemodynamics, arterial stiffness and small airways in a resting situation prior to the spiroergometry and their alteration during the 30 minutes time period after the workout. During this time period,"Mobil-O-Graph"-measurements will be taken in a 5 minute interval, small-airways-airwave-oscillometry through "tremoFlo" after 5, 10, 15 and 30 minutes. Additionally the parameters of physical perfomance will be compared amongst each other. | — |
Countries
Germany
Contacts
Public ContactMaximilian Funck
Universität zu Lübeck/ UKSH - Campus Lübeck, Medizinische Klinik III (Pulmologie)
Outcome results
None listed