coronary artery disease aortic valve stenosis primary mitral valve regurgitation
Conditions
Interventions
Group 1: isolated on-pump coronary artery bypass grafting (CABG)
Group 2: isolated off-pump coronary artery bypass grafting (OPCAB)
Group 3: isolated biological aortic valve replacement (AKE)
Group 4:
Sponsors
Klinik für Anästhesiologie und Operative Intensivmedizin, Uniklinik Köln
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. age of 18 years or older 2. written informed consent 3. preoperative sinus rhythm 4. sinus rhythm or atrial pacing after termination of extracorporeal circulation 5. preoperative preserved biventricular function 6. uneventful intraoperative course 7. For CAGB and OPCAB patients: no significant heart valve disease 8. For AKE patients: severe aortic valve stenosis, no other significant heart valve disease 9. For MKE and MKR patients: primary severe mitral regurgitation, no other significant heart valve disease
Exclusion criteria
Exclusion criteria: 1. severe pulmonary hypertension (pulmonary artery pressure >45 mmHg) 2. Redo procedure 3. Patients with contraindications to transesophageal echocardiography 4. intraoperative complications (e.g. shock, mechanical circulatory support after weaning from bypass, severe bleeding, difficult or complex weaning from bypass, change of surgical procedure, rethoracotomy) 5. For CABG and OPCAB patients: incomplete revascularisation 6. For AKE and MKE patients: more than mild paravalvular leakage, more than mild patient-prosthesis mismatch 7. For MKR patients: more than mild mitral valve regurgitation, more than mild mitral valve stenosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative course of left and right ventricular strain. Strain analysis is performed with EchoPAC v204 (GE Healthcare, 9900 Innovation Drive Wauwatosa, WI 53226 U.S.A.) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Intraoperative change of conventional parameters of myocardial function 2. Correlation of strain-based parameters with postoperative patient outcome 3. HR Subgroup: Effect of heart rate on strain-based parameters | — |
Countries
Germany
Contacts
Public ContactJakob Labus
Klinik für Anästhesiologie und Operative Intensivmedizin, Uniklinik Köln
Outcome results
None listed